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IDD Therapy Offers Non-Surgical Back Pain Relief

May 31, 2007

Suffering from acute or chronic lower back pain? There is an innovative treatment option at the Advanced Physical Medicine Center locally in Fairview, N.J, which will get you back on your feet.

“There are only a handful of these machines in Bergen County,” explains Dr. Michael Arber, a chiropractor at the center, who administers non-invasive Intervertebral Disc Decompression (IDD) therapy. “The best part about the equipment is that it’s not just temporary relief. It actually reduces the size of disc injuries and helps the surrounding soft tissue return to normal function.”

Thanks to IDD Therapy, a non-surgical treatment, approximately 85 percent of people can relieve back pain symptoms without drugs or surgery. This revolutionary technology is ideal for herniated or bulging discs, degenerative disc disease, spinal stenosis, sciatica and acute or chronic back pain.

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IDD therapy is deployed via the Accu-SPINA System, and works to reshape the spine using computer technology to apply traction to spots causing lower back pain. The traction provides a negative pressure that allows fluid, blood and nutrients into the affected discs that cause pain. In other words, as each challenge is introduced to the body, it supports muscles and ligament tissue to retone itself, re-educating the neuromuscular system and relieving pain. The typical treatment is 18 to 24 treatments over eight weeks, and each session lasts 30 minutes.

“It’s not painful. Once on the machine, a lower harness pulls at a specific angle and tension to alleviate the area of stress,” says Dr. Arber. “While IDD therapy is not currently reimbursable by insurance carriers, the cost of getting lower-back surgery is far greater. And IDD therapy is non- invasive.”

Dr. Arber says a lumbar MRI and an exam is all that is needed to determine if IDD therapy is right for a patient.

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Surgery beats drugs and therapy for treating common back ailment

May 31, 2007

Surgery is twice as effective as physical therapy and drugs for relieving pain and improving mobility in one of the most common back problems, researchers reported today.

The study, published in the New England Journal of Medicine, gives “us more confidence in recommending surgery to our patients,” said Dr. Mark J. Spoonamore of USC’s Keck School of Medicine. The recommendation is “not just our gut feeling but based on a strong scientific foundation.”

Dr. Arya Shamie of UCLA’s David Geffen School of Medicine added, “This is a great study … confirming what doctors have believed all along.”

The condition, called degenerative spondylolisthesis with spinal stenosis, occurs when one lumbar vertebra in the back slips forward relative to the one next to it, pinching the spinal cord and producing severe pain in the legs.

The condition affects as many as 600,000 Americans, although only about half of those seek medical treatment and perhaps only a quarter of them undergo surgery, according to Dr. James W. Weinstein of the Dartmouth-Hitchcock Medical Center in Hanover, N.H., who led the study.

The bulk of the patients are older than 50, and women are six times as likely as men to suffer from it, with African American women at greatest risk.

Conventional treatment involves physical therapy, steroids to reduce swelling and anti-inflammatory drugs. But only about 20% of patients get better and 20% stay the same without surgery, according to Shamie, who was not involved in the study.

Surgery relieves pain by removal of bone and soft tissue in a procedure called a decompressive laminectomy.

Because of the aging American population, back surgeries are one of the fastest-growing areas of medical care, with hospital costs totaling more than $21 billion per year, according to Dr. Richard A. Deyo of the University of Washington.

The federally funded study enrolled 607 patients at 13 medical centers in 11 states. Of those, 372 underwent surgery and 235 did not.

Two years after their enrollment in the study, the patients who did not undergo surgery reported only modest improvements in their condition.

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Those who had surgery reported significantly reduced pain and improved functionality. Major improvements were seen within six weeks after the surgery. The most common complication of the surgery was a tear in the lining of the spinal cord.

“Up until now, we suspected surgery produced better results, but we had little objective data to support that,” Weinstein said.

“With the results of this study, we can now discuss much more fully the surgical and nonsurgical options available to our patients so that they can make an informed choice.”

In a second study in the journal, a Dutch team led by Dr. Wilco C. Peul of the Leiden University Medical Center studied 283 patients with severe sciatica, which produces a burning pain in the sciatic nerve that runs down the outside of the leg. The pain is caused by herniated disks in the spine that put pressure on the sciatic nerve.

Peul and his colleagues reported that sciatica patients undergoing surgery got much faster relief from the pain than those receiving only physical therapy and drugs, but that at the end of a year, 95% of patients in both groups were largely free of pain.

Those results were similar to findings reported by Weinstein and his colleagues last year in a much larger study — although Weinstein found a small but persistent benefit from surgery.

In a third track of the U.S. study, Weinstein and colleagues will report later this year on the benefits of surgery for patients with spinal stenosis — a narrowing of the spinal column — caused by degenerative arthritis.

The team is also following all of the patients in the three tracks for 10 years to see how well the treatments hold up with time.

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Gentle dental: New techniques and technologies are helping patients who quake at the words, ‘Open wide’

May 29, 2007

Once a military dentist, Dr. A. W. Mercier Jr. says he can’t forget the burly fighting men who “could kill me if I sneezed,” but were nevertheless terrified of him.

“They looked up with fear in their eyes and said, ‘Don’t hurt me, Doc.’ ”

Today, to gain the trust of those who are too riddled with anxiety even to come to the office, Dr. Mercier has met new patients at coffee shops. “Once you gain their trust, you can help them.”

Dr. Mercier, who has his practice in South Dartmouth, uses air abrasion and hand-tool techniques to remove cavities. The combination, he says, is usually painless since the vibrations and heat of the traditional drill are eliminated. Often, no local anesthetic is needed. This is just one of many options for people who avoid dentists out of fear.

If the words “open wide” make you break out into a sweat, you are not alone.

The Massachusetts Dental Society reports that seven out of 10 people get clammy palms before going to the dentist, and between 30 and 40 million Americans are so afraid that they live with oral infections and pain rather than get the care they need.

For dentophobics, the descriptors “gentle dental” and “pain free” promise relief. They are catch phrases for new techniques and technologies that promise to take the anxiety out of sitting in the dentist’s chair, and they are showing up in a lot of advertising.

“The mouth is a very personal place. To have pain in there is a serious violation,” says Dr. Michael Jusseaume, who has a practice in Westport and is the Southeastern District Trustee for the Massachusetts Dental Society.

One way to make a dental visit less threatening is, obviously, to eliminate discomfort. Dr. Joel Weaver, director of anesthesiology for Ohio State University College of Dentistry, says that new drug compounds and slick methods of giving injections are making local anesthesia more effective than ever.

If blocking pain is the key to making people less anxious in the dental chair, then why are many still afraid?

Fear of the needle is a common problem. But, needles are so fine that along with topical numbing gels you’re not supposed to feel the puncture anymore. Doctors say that what stings is the pressure of the anesthetic entering gum tissues.

For that there is “The Wand,” a computer controlled syringe that delivers anesthetic in tiny doses. It’s touted as one of the new pain-free technologies. However, the injection takes longer, and most people want a needle out of their mouths quickly, Dr. Weaver says.

For those who sit rigid with anticipation that they might feel pain, the fast-acting inhaled sedative nitrous oxide (also called “laughing gas” for its ability to relax people to the point of giggling) has been used for decades as a calming agent. It is easy to regulate; with only a few deep breaths of air, patients clear their heads.

Dr. Michael Katz of Westport describes the effects of nitrous oxide as “almost like having a couple of drinks. There is no danger of loss of consciousness. It raises the pain threshold and makes time go by quickly.”

Virtual vision headsets are a drug-free alternative that Dr. Katz offers to reduce anxiety and make long appointments more comfortable. Watching a movie through the headsets gives patients an unobstructed view while the dentist works in their mouths. “It takes their minds off what we’re doing. It helps. I don’t know why more people don’t have them,” Dr. Katz says.

Of his gentle approach, he says, “I’m not doing anything that shouldn’t be done on a routine basis (by all dentists).”

Never mind being treated by a dentist, even the idea of being in a dental office, with its odors and sounds, is too much for some people. Anxiolysis (a fancy word for taking a mild sedative like Valium ahead of time) could be an answer and dentists are qualified to prescribe the medications.

Lisa Majewski of Swansea avoided the dentist for 10 years after a bad experience with a root canal. For her, Dr. Katz prescribed a mild sedative. “I’ve had two kids, but when it comes to my mouth I’m a big baby,” she says. “My biggest fear was getting hurt again and having someone make me feel bad for not going (to the dentist) for a while.”

Thanks to his gentle manner, medication and watching a movie on the headsets, Mrs. Majewski has been able to let Dr. Katz complete gum surgery, a root canal and two crowns.

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Sedation dentistry is a relatively new phenomenon that some people turn to who have developed major dental problems but cannot face the necessary work while remaining awake. Short of general anesthesia, there is an option called “conscious sedation” that allows the patient to be in what’s commonly called a “twilight state” without the need for hospitalization. Dr. Jusseaume says that conscious sedation is a “whole lot safer. The least amount of drugs is always the best. Every time someone is put to sleep they might not wake up.”

However, some patients determined to be completely knocked out go to the West Coast where general sedation dentistry is more common. One such practitioner is Dr. David Blende of San Francisco, who features “sedation dentistry for the fearful, phobic and special needs patient.”

Over the past 20 years, Dr. Blende has treated patients with severe dental phobias from 26 states and 16 countries, according to practice manager Amanda White. Often, their patients want to have decades of neglect cared for all at once. She says that the Blende Group is the “national leader in definitive full-mouth rehabilitation.”

While anesthetized in a hospital operating room, specialists can perform crowns, root canals, gum surgery, extractions and fillings that would normally require many dental visits. “A lot of patients, once they get through this massive process, are able to go in to a dentist for regular maintenance,” Ms. White says.

While medical insurance may cover the cost of the hospitalization, patients still need to cover the fees for all of the dental work. The bill for this specialized care can add up to the cost of a mid-sized car.

One of Dr. Blende’s patients flew across country from the Boston-area and forked over $25,000 to be sedated for a full mouth cleaning, five extractions, four crowns, four veneers and eight fillings.

Brian (who asked that his last name not be disclosed) says that he neglected his dental needs for 20 years following bad experiences as a youngster treated by novices at a dental school clinic. For Brian, even simple cleanings were out of the question.

“The whole idea of metal scraping my teeth terrified me. Sitting in the chair and having someone prodding around in my mouth was something I couldn’t do.”

In general, dentists seem to prefer not to use sedation partially because, in the long run, it does not help patients get over their fears. Dr. Jusseaume says that none of the modern gadgets or medications can substitute for a good old-fashioned relationship of trust between dentist and patient.

Mattapoisett resident Karen Cosgriff chose her dentist, Dr. Joseph Mills of Dartmouth, specifically because a friend recommended him as trustworthy. After years of avoiding dentists because of past problems with pain and gagging, she says, “I really like this guy. He’s quick. He doesn’t spend a lot of time with his fingers in my mouth making conversation. By the time I start to become my paranoid neurotic self, it’s over.”

Those who have trouble trusting dentists tend to be people 50 years of age or older who had painful experiences with techniques that are less refined than they are now, Dr. Jusseaume explains.

For the younger generation, he says, going to the dentist is not particularly scary. “Kids today are growing up with dentistry that is performed kindly and gently.”

The American Dental Society does not recognize a specific specialty in gentle dentistry. However, Dr. Michael Krochak of the Dental Phobia Treatment Center of New York says that “a lot of dentists do it intuitively.”

To find a gentle dentist the patient needs to “feel empowered to search. If you don’t get a warm-fuzzy on the first visit, move on.”

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New pain relief option for migraine sufferers

May 24, 2007

Migraine sufferers have a new pain relief option, with the addition of a new generic drug to Pharmac’s list of fully funded medications.

The government drug funding body announced today it would fund generic sumatriptan tablets — new forms of GlaxoSmithKline’s migraine relief drug Imigran.

The drug is used to relieve migraine headaches as they occur.

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The patent on Imigran ran out in April 2006.

GlaxoSmithKline has agreed to lower the cost of Imigran, so it will continue to be available, Pharmac medical director Peter Moodie said.

Pharmac will save $21 million over the next five years as a result.

“Migraines impact on a number of New Zealanders and Pharmac is pleased to be able to continue giving them access to a medicine they trust and to free up funds that we can use to purchase other medicines,” Dr Moodie said.

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New Study Demonstrates that Lubiprostone May Improve Symptom Relief Rates in Adults with Irritable Bowel Syndrome with Constipation (IBS-C)

May 21, 2007

WASHINGTON, May 21 /PRNewswire/ — A new study demonstrated that the active ingredient in AMITIZA(R) (lubiprostone), given 8 mcg twice a day, may improve symptom relief rates in adults with irritable bowel syndrome with constipation (IBS-C). These results were presented as a late-breaker at Digestive Disease Week 2007, the largest annual international meeting of digestive disease specialists. “In this study, patients receiving lubiprostone were nearly twice as likely to achieve an overall response from symptoms of IBS-C compared to those receiving placebo,” said Douglas A. Drossman, M.D., primary investigator, UNC Center for Functional GI and Motility Disorders, University of North Carolina, and the Chair of the Rome Committee. “As a result, lubiprostone may represent an important treatment for IBS-C sufferers.” IBS is a condition that affects approximately 58 million Americans and accounts for 25-50 percent of referrals to gastroenterologists. IBS-C symptoms include abdominal pain or discomfort associated with defecation or a change in bowel habits with features of disordered defecation. Lubiprostone is a novel selective chloride channel activator that has been shown to be effective and well-tolerated in a number of well-controlled clinical trials in patients with chronic idiopathic constipation. Lubiprostone is marketed in the U.S. as AMITIZA, a 24-mcg gelcap that was approved for use for chronic idiopathic constipation in adults on January 31, 2006. Sucampo Pharmaceuticals expects to submit a supplemental New Drug Application for IBS-C to the U.S. Food and Drug Administration by July 2007. About the Study for IBS-C (lubiprostone 8 mcg) In two phase III, multi-center, double-blind, randomized, placebo- controlled trials, 1,171 adults diagnosed with IBS-C (Rome II Criteria) were enrolled and received lubiprostone 8 mcg taken twice daily (783 adults) or placebo (388 adults) over a 12-week period. Primary efficacy was determined by a unique question: “How would you rate your relief of IBS symptoms (abdominal discomfort/pain, bowel habits and other IBS symptoms) over the past week compared to how you felt before you entered the study?” A 7-point balanced scale with a strict evaluation using the two highest scale points to qualify as a responder was used. Patients were considered monthly responders if they reported at least moderate relief four out of four weeks or significant relief two out of four weeks. To qualify as an overall responder (the measure used in the primary endpoint), patients had to be a monthly responder for at least two out of three months. During the evaluation period, patients discontinuing for any reason or reporting an increase in rescue medication use, lack of efficacy or moderately or significantly worse relief were deemed non-responders. These responder rates may not be comparable to those in other studies since the new scale was more restrictive than those used in previous reports. The findings demonstrated that patients receiving lubiprostone 8 mcg twice daily were nearly twice as likely to achieve overall response compared to those receiving placebo (lubiprostone 17.9 percent vs. placebo 10.1 percent, P=0.001). There was a similar incidence of serious adverse events (1 percent in each group) and related adverse events (lubiprostone 22 percent vs. placebo 21 percent) compared to placebo. The most common treatment-related adverse events (greater than or equal to 5% of patients) were nausea (8 percent vs. 4 percent, respectively), diarrhea (6 percent vs. 4 percent, respectively) and abdominal pain (4 percent vs. 5 percent, respectively).

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About Irritable Bowel Syndrome with Constipation (IBS-C) Irritable bowel syndrome (IBS) is a chronic disorder characterized by abdominal discomfort and pain, and bowel habit changes including symptoms of constipation and/or diarrhea. The condition can significantly interfere with daily activities and reduce patients’ quality of life, resulting in absences from school, missed work and reduced productivity. Three main types include IBS with constipation (IBS-C), with diarrhea (IBS-D) and with mixed symptoms of constipation and diarrhea (IBS-M). In IBS- C, symptoms are present for at least 3 days per month over a 3-month period. Although people with IBS-C report suffering from many of the same symptoms associated with constipation, the presence of abdominal discomfort and pain is what differentiates IBS-C from chronic constipation. Additionally, the hypersensitivity of the gastrointestinal system of individuals with IBS makes them more prone to experience the effects of even mild symptoms of constipation or diarrhea. The condition is approximately 2 to 2.5 times more prevalent in women than men, and women are more likely to report a history of constipation. About AMITIZA(R) (lubiprostone) 24 mcg BID for Chronic Idiopathic Constipation AMITIZA is indicated for the treatment of Chronic Idiopathic Constipation in the adult population. AMITIZA should not be used in patients with a known hypersensitivity to any components of the formulation and in patients with a history of mechanical gastrointestinal obstruction. Patients with symptoms suggestive of mechanical gastrointestinal obstruction should be evaluated prior to initiating AMITIZA treatment. The safety of AMITIZA in pregnancy has not been evaluated in humans. In guinea pigs, lubiprostone has been shown to have the potential to cause fetal loss. AMITIZA should be used during pregnancy only if the benefit justifies the potential risk to the fetus. Women who could become pregnant should have a negative pregnancy test prior to beginning therapy with AMITIZA and should be capable of complying with effective contraceptive measures. AMITIZA should not be administered to patients that have severe diarrhea. Patients should be aware of the possible occurrence of diarrhea during treatment. If the diarrhea becomes severe, patients should consult their health professional. In clinical trials for Chronic Idiopathic Constipation (24 mcg BID), the most common adverse event was nausea (31%). Other adverse events (greater than or equal to 5% of patients) included diarrhea (13%), headache (13%), abdominal distention (7%), abdominal pain (7%), flatulence (6%), sinusitis (5%) and vomiting (5%).

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Chronic pain hinders memory: U of A study (7:48 p.m.)

May 21, 2007

EDMONTON - When Deana Adams sliced her left hand on a sharp piece of steel at work more than three years ago, doctors gave her four stitches, unaware that the nerve between her thumb and index finger had been severed.

The pain since then - like a shock from an electric fence that runs up her arm to her shoulder, neck and head - has been at times so severe it has affected her marriage, interrupted her sleep and stolen the good memory she prided herself in.

“I forget things really easily,” said Adams, who works as a surgical processor at the University of Alberta hospital, sterilizing, decontaminating and organizing hundreds of pieces of hospital equipment. “The pain takes over. It sort of just swarms in and says, Here I am, listen to me,’ and you want to do anything to relieve it.”
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Adams’ memory problems are common among chronic-pain sufferers, says new research from the University of Alberta.

Bruce Dick, a clinical psychologist at the Multidisciplinary Pain Centre at the U of A hospital, discovered two-thirds of people with chronic pain had some measure of cognitive impairment that shortened their attention spans and made it difficult to remember things. Half of those people had significant memory issues, especially when multi-tasking.

Dick tested their working memory, similar to short-term memory but more in charge of remembering items on a moment-to-moment basis. They would have difficulty, for instance, remembering a phone number as they ran to find a pen. They may also struggle to fully remember short conversations.

Even when the patients received short-term relief from their pain through injections into the spine or massages on trigger points, the patients continued to have memory and attention problems.

“Chronic pain is something that is disruptive,” said Dick, whose research paper appeared in this month’s edition of the journal Anesthesia and Analgesia. “Part of the rational for doing this study is, we have some fairly good medical treatments aimed at helping relieve pain. What’s more difficult sometimes is affecting the bigger picture of people’s lives, so trying to lesson the disability or helping improve people’s quality of life.

“It’s one thing to alleviate someone’s pain, but quite another to help people get back into playing with their kids or picking up their grandchildren or being able to go to work and follow a regular schedule.”

Knowing that chronic-pain sufferers may have difficulty remembering certain details during their day, pain therapists may be able to develop new strategies to help patients overcome the gaps.

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Adams works through her memory lapses with cue cards that list the intricacies of putting together full surgical sets at work. If she’s called away from a task, the notes help keep her on track.

When she’s the relief supervisor, she writes staff names with corresponding duties.

At home, Adams’ attention has also suffered. She used to plow through paperbacks within hours, but now picks up a half-read book and can’t remember the plot line. She forgets conversations and birthday cards she’s sent.

On bad days, when her hand swells and pain shoots up her left arm, she can’t sit through an hour of TV because the noise irritates her.

It used to be worse.

“Emotionally, when it first happened, I got depressed really bad,” she said. “When you’re in pain, you don’t want anyone to touch you. You don’t sleep. You don’t eat. You’re constantly on guard.”

Since then, she has cut back on her medication, but still takes 27 different pills throughout the day.

She sometimes wonders if the medication impedes her memory. At other times, she wonders if she’s losing her mind and just stupid for needing reminder notes at the age of 41.

Dick, who controlled for medication effects in his study, hopes his study changes such thinking.

“I would hope it would provide some validation for the people who suffer with these complex pain problems,” he said. “It can be easy for a patient to jump to a conclusion that I’m crazy,’ or others may think that person is a wimp or just not motivated and doesn’t feel like going back to work. We hope that sometimes by increasing the general knowledge about a problem, we can take away some of the stigmas related to what happens to these people in their lives.”

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Giambi looks for foot relief

May 16, 2007

CHICAGO — Slumping New York Yankees designated hitter Jason Giambi might have a solution for his aching left heel.

He went to an orthopedic specialist in Los Angeles on Monday to get some new shoe inserts to alleviate the pain caused by a bone spur in the heel.

“I got some more orthopedics made just to cover all my bases,” Giambi said. “He gave me a different pair to try on for my shoes to see if they would help out a little more.”

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Giambi expects to have the inserts by Friday and was given some temporary ones that are different from the ones he had been using.

“They’re hoping that they can, with the orthodics, alleviate some pain and I can get rid of the pain in my spur,” he said.

“I’ve never really had a problem with the spur, up until lately. I think my heel is inflamed because of everything that’s gone on.”

Giambi was hitless in his last 18 at-bats. He said the heel was affecting him at the plate.

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Tarrytown man charged with stealing pain meds from pregnant woman

May 15, 2007

A physician’s assistant from Tarrytown is facing charges in Stamford, Conn., for disconnecting a pump that was supplying pain medication to a sleeping pregnant woman, then stealing the pump and the drugs in order to provide relief for his dying dog, officials said.

Preston Goldsmith, 33, reportedly told hospital security officers that he stole the drug Fentanyl and equipment at Stamford Hospital from a woman awaiting an induced labor procedure in October. Goldsmith turned himself in to Stamford police on Saturday to face charges of illegally obtaining a controlled substance, illegal possession of a narcotic, third-degree larceny and reckless endangerment.

According to a court affidavit, Goldsmith initially told security officers that he threw the drugs and the pump out of his car along the Merritt Parkway. Investigators never recovered the items, and a month later he recanted his story.

Stephan Seeger, a lawyer representing the woman, called the crime, “cowardly and egregious.”

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“In the state of Connecticut, like in the state of New York, there are enhanced penalties that are applicable to people who are referred to as vulnerable victims,” Seeger said. “And I can hardly imagine any circumstance where a victim is more vulnerable than a defenseless and helpless woman shortly before she goes into childbirth, hooked up to tubes including one that is providing the pain medication she needs to get through the procedure.”

Goldsmith’s lawyer, Philip Russell, said his client maintains his innocence and will enter a not guilty plea at his next court appearance scheduled for Friday at Connecticut Superior Court in Stamford. “It’s too early to comment on the evidence or to say anything much more complex, but at this juncture I fully expect that a thorough examination of the facts will result in a favorable resolution” Russell said.

According to New York state records, Goldsmith has been a licensed physician’s assistant since 1998 with no disciplinary history. He worked at Stamford Hospital from August 2006 until October, when he was fired.

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Pain-relief review points to acupuncture for aching backs

May 10, 2007

A review into the recommended actions for a mother-to-be who is suffering from muscular pain has recommended gentle stretching exercises and acupuncture as a means of pain relief.

Towards the end of the pregnancy, many expectant women find that their muscles begin to show some strain, with two-thirds of pregnant women reporting back pain and almost one-fifth complaining of pelvic pain.

Lead author of the review, Victoria Pennick, said that the American study which looked at 1,305 pregnant women from Sweden, Iran, Brazil, Thailand and Australia showed that women who participated in prenatal exercise programmes testified to significant decreases in back pain compared to women who received the usual prenatal care.

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The Ozzlo pillow, a curved, soft cushion designed to support the pregnant abdomen when lying down, was also found to be effective and 60% who received acupuncture reported less intense pain, compared to 14% of women who found not difference in pain levels.

Ms Pennick said that although more tests were needed before a concrete answer could be given, the studies were more advanced than those carried out previously in this field and suggested that different actions would benefit different mums-to-be.

“It’s really important to talk it over with your own primary care provider and decide together what’s right for you,” she concluded.

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Priced out of pain relief

May 8, 2007

Alexa Wild, a San Jose State University freshman, says the chronic pain in her hands and feet is getting worse, a sign the drugs she is taking to combat rheumatoid arthritis are no longer working.

Her doctor has recommended increasing her dosage of Remicade, an intravenous drug used to treat inflammatory conditions. But Wild, who is covered by her mother’s health insurance plan, can’t afford a higher dose.

“It’s so expensive, and the insurance only covers so much,” said Wild, a former competitive cheerleader and swimmer from San Bruno. “If I were to get more … there’s no way we could afford that.”

Health insurers routinely require patients to pay a portion of their medication costs. But the stakes are becoming a lot higher as an increasing number of high-priced biologic drugs come to market. Such drugs are based on substances produced by living cells.

Rheumatology patients such as Wild have been hit especially hard because the field has benefited from the introduction of a number of newer biologic drugs, including Remicade, Enbrel and Humira.

Biologic drugs are also used to treat cancer. But cancer drugs are used for limited periods of time. By contrast, rheumatic conditions such as arthritis are chronic, degenerative diseases that require long-term, possibility indefinite, treatment. In such cases, high-priced medication imposes a punishing — and continuing — financial burden.

Remicade, for example, costs third-party payers an average of $19,000 to $22,000 a year per patient, according to the drug’s developer, Centocor Inc. Many health insurance policies have out-of-pocket maximums that limit a patient’s expenses. But those maximums vary greatly, leaving many insured individuals to face thousands of dollars in annual expenses.

That may not be the only problem patients must deal with. In addition to high co-payments, some patients and doctors say insurers may be delaying approval of these medications and, in some cases, rejecting previously approved claims, in order to save money.

In Wild’s case, her Blue Shield of California plan covers 70 percent of negotiated medication and infusion rates. The additional vial of Remicade her rheumatologist has recommended would add $158 to the $736 bill she and her mother struggle to pay for each bimonthly treatment.

Her doctor, Michael Stevens of San Mateo, is frustrated by what he says are insurance practices that discourage patients from taking proper doses of medications. To compensate, Stevens said he often has to prescribe higher doses of older therapies such as methotrexate, which costs hundreds rather than thousands of dollars a year but can cause serious side effects.

“Insurers are deciding what’s appropriate for their ‘clients,’ who are our patients,” Stevens said. “They have their own committees, which are biased, and they decide the appropriate treatment. They don’t look at what the physicians in the community are doing and what is the standard of care.”

Stevens has been paid by Remicade’s maker for speaking engagements.

Dr. Michael Schweitz, a rheumatologist in West Palm Beach, Fla., said insurers have started denying reimbursement for one biologic infusion out of a series of treatments a patient regularly receives.

“It’s part of a pattern of what appears to be capricious and irregular delays in payments that make no logical sense,” said Schweitz, adding that the treatment ultimately gets approved after considerable effort.

Insurers, for their part, say they are simply adhering to standards based on scientific evidence that have demonstrated the best medical outcomes.

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“All of us have a role in promoting evidence-based medicine,” said Susan Pisano, spokeswoman for America’s Health Insurance Plans, the industry’s trade group. “If health plans were not aligning themselves with the principles of evidence-based medicine, we should be called into question about that.”

Pisano added that insurance guidelines are not set in stone. “There’s always a way for a physician who (wants) to make the case that a particular patient requires something that’s a little different to make that case,” she said.

Coverage also varies substantially depending on what type of plan patients or their employer purchased, said Nicole Kasabian Evans, spokeswoman for the California Association of Health Plans. She said insurers typically do not treat biologics differently than other brand-name drugs.

The problem is not limited to rheumatology patients. Vicky Wheeler of Menlo Park started taking Enbrel in 2005 for psoriasis, a dermatological condition. Her insurer, Health Net, covered the drug completely. But now Health Net requires Wheeler to pay 30 percent, or about $400 a month, for the self-injected drug.

The National Psoriasis Foundation estimates biologics such as Enbrel cost between $10,000 and $25,000 a year per patient.

“I finally found something that made it completely go away, and then I couldn’t get it,” said Wheeler, 41, who had to cut her dosage in half so she could afford the drug. She has since found an aid program to help her cover the cost.

Centocor, a biotech company owned by Johnson & Johnson, last week announced a new patient-assistance program designed to cover co-payments for qualified new Remicade users. Spokesman Michael Parks said the company acted in response to patient concerns over the cost of Remicade, Centocor’s top-selling drug, with $3.8 billion in sales last year.

In Congress, Sen. Edward Kennedy, D-Mass., is leading an effort to enact legislation allowing the federal government to speed up the approval of generic biologics.

Joanna Smith of Healthcare Liaison in Berkeley, an intermediary between patients and insurers, said insurers commonly require patients to try cheaper, alternative drugs before approving an expensive therapy.

“But I don’t see a particular limit in the ways insurers are going to push on the medication issue,” Smith said. “Drugs are expensive and (insurers) are cutting costs. Patients are trying to get as much out of their plans as possible.”

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