PAIN RELIEF MEDICATIONS BLOG

The Foundation of Back Pain

August 30, 2007

8 out of 10 men and women will look for lower back pain relief at some point in their life. Tenderness in the lower or middle back is the leading cause of disability and pain in people less than the age of 45.

Back pain can vary from a gentle, unrelenting ache to unbearable pain with the least amount of movement. There are numerous reasons for requesting back pain remedies. The majority of occurrences are associated with soft tissue inflammation surrounding the spinal columm.

Is Back Pain Common?

At least fifteen million men and women search for medical assistance in regards to lower back pain relief each year. Lower back pain relief is runner up to the common cold as a cause of days of work lost and visits to the local pharmacy. Consequently, the market for lower back pain assistance is significant.

What Causes Back Pain?

Back muscular weakness is primarily a result of an inactive routine. This takes account for back pain relates to stress. Back spasms also begins with laborious activities, or if you shift rapidly after staying in an uncomfortable position. Often following a repetitive twisting movement is when a “pulled back” takes place. Lower back pain medications line the shelves of supermarkets and pharmacies, as the necessity for lower back pain relief is widespread. Keep in mind most medications do not heal at the root of the problem like Recovery. Other products are going to be nothing more than a band- aid to your current condition.

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The intervertebral disks perform as shock absorbers and are exposed to diverse types of pressure and strain throughout the course of daily activities and living. These stresses and tensions outcome may not produce back pain in the moment. In fact, the harm is in fact slowly taking place, the continual trauma start to take its toll. Turning, bending as well as twisting produces compression of the disk, and may cause it to bulge or herniate back towards the nerves and spinal canal. Bending and twisting collectively creates utmost stress on intervertebral disks. Disk degeneration will show its self as chronic or sharp back pain as the muscles preserving the disks go into spasm. The disk degeneration may become inflamed and may possibly cause joint or structural pain.

The lower back known as the lumbar region is the most susceptible to damage. This region receives the more work and use than any other part of the body. This area of the spine tolerates all the burden of the upper body. It bends, twists, flexes and turns on a daily basis. Depending on the amount of strain we put on the lumbar areas will reflect on the amount of wear and tear.

The more wear and tear on the back will ultimately illustrate itself as back pain. This pain is representing damage to the soft tissue which is made up of muscles, ligaments, tendons and the intervertebral disks. The pain is an inflammatory development, a breakdown of the tissue.

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Futura appoints adviser on pain relief

August 23, 2007

Consumer healthcare group Futura Medical, has appointed Professor Robert Moore DSc as an advisory consultant to the company in the therapeutic area of pain relief. The company said Prof Moore’s extensive experience of pain relief, from both academic and commercial perspectives, is expected to be of great value in the development of TPR100, its topical treatment for the provision of pain relief.

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Prof Moore, a former Consultant Biochemist at the Radcliffe Infirmary, Oxford, has published many scientific articles. He moved into industry in 1985 as managing director of the UK division of a US diagnostics company, taking it from six to 250 employees and achieving profitability. In 1994, he established his own healthcare consultancy, which has worked for many of the world’s leading pharmaceutical companies, and he has also advised Government.

James Barder, Futura’s chief executive, said: “I am delighted to welcome a scientific adviser of Prof Moore’s calibre to Futura. His huge breadth of experience, particularly in the area of pain relief, will be of great value in the development of TPR100, our pipeline product that uses our topical trans-dermal delivery technology, DermaSys.”

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Roche Diagnostics’ Test Helps Doctors Determine Appropriate Pain-Relief Treatment for Nursing Mothers

August 18, 2007

FDA Issues Advisory Warning Nursing Mothers of Potential Effects of Codeine While Nursing INDIANAPOLIS, Aug. 17 /PRNewswire/ — Nursing mothers can be tested with Roche Diagnostics’ AmpliChip CYP450 Test to help their doctors determine whether they are ultra-rapid metabolizers of codeine. The Food & Drug Administration issued a Public Health Advisory on Friday warning nursing mothers about the potential negative effects of codeine while nursing. The advisory is posted at http://www.fda.gov/cder/drug/advisory/codeine.htm. Roche Diagnostics is the only company that makes an FDA-cleared test for determining a patients’ CYP2D6 genotype, which helps a doctor predict how patients will metabolize certain drugs, including codeine. The AmpliChip test analyzes variations in two genes — CYP2D6 and CYP2C19 — that play a primary role in the metabolism of some drugs used to treat severe depression, schizophrenia, bi-polar disorder, cardiovascular disease treated with beta-blockers, attention deficit/hyperactivity disorder (ADHD) and others. Knowledge of these gene variations can be used to help individualize drug treatment through selection of the more appropriate drugs and adjustment of dosages. These measures have the potential to improve patient outcome by reducing adverse drug reactions and improving drug efficacy.

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For a list of laboratories offering AmpliChip CYP450 Test, go to http://amplichip.us. About Roche and the Roche Diagnostics Division Headquartered in Basel, Switzerland, Roche is one of the world’s leading research-focused healthcare groups in the fields of pharmaceuticals and diagnostics. As a supplier of innovative products and services for the early detection, prevention, diagnosis and treatment of diseases, the Group contributes on a broad range of fronts to improving people’s health and quality of life. Roche is a world leader in diagnostics, the leading supplier of drugs for cancer and transplantation and a market leader in virology. In 2006, sales by the Pharmaceuticals Division totaled 33.3 billion Swiss francs, and the Diagnostics Division posted sales of 8.7 billion Swiss francs. Roche employs roughly 75,000 people in 150 countries and has R&D agreements and strategic alliances with numerous partners, including majority ownership interests in Genentech and Chugai. Roche’s Diagnostics Division offers a uniquely broad product portfolio and supplies a wide array of innovative testing products and services to researchers, physicians, patients, hospitals and laboratories world-wide.

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Australian Drug Regulator Cancels Registration of Prexige

August 15, 2007

Australia’s drug regulator, the Therapeutic Goods Administration (TGA) has cancelled the registration of the osteoarthritis drug Prexige because of serious liver side effects associated with the use of the drug.

According to the TGA, Novartis’ Prexige (lumiracoxib) is a Cox 2 inhibitor belonging to the group of medicines known as non-steroidal anti-inflammatory drugs.

Prexige was first approved in Australia in July 2004, but has only recently become widely used since being listed on the Pharmaceutical Benefits Scheme in 2006, the agency added.

As of Aug. 10, According to the Rohan Hammett, TGA’s principal medical adviser, the agency had received eight reports of serious adverse reactions to the drug, including two deaths and two liver transplants.

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Approximately 60,000 Australians take Prexige for symptomatic relief of osteoarthritis, acute pain — including postoperative pain and pain related to dental procedures — and pain due to primary dysmenorrhoea, the agency added.

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Good Posture: Back Pain Relief

August 7, 2007

Having a good posture does not only make one’s personality more appealing but it keeps our bones and joints in the correct alignment to keep our muscles perform its movements normally and function excellently. Maintaining a good posture minimizes pressure on the spine, thus, the chance of getting backache and muscular pain becomes minimal.
One must be aware of his or her own posture in order to have a conscious effort to correct a bad posture, which is a result of a person’s habitual way of carrying the body from head to toe. Aside from a bad posture habit, a lot of factors may contribute to having a bad posture such as obesity, pregnancy, weak muscles, high-heeled shoes, tight muscles and poor work environment among others.
A good posture is not limited to standing erect but also applies to correct sitting position as well as lying down.
Body Mechanics and Ergonomics
Maintaining proper posture while performing movement is called body mechanics. Faulty body mechanics may be due to some constant stress over a long period of time and may also lead to injury. Working some adjustments in your environment to encourage good body mechanics is called ergonomics. This entails a change in work station, or doing alterations or modifications to any task or habit.
Back Pain
Our back serves as the workhorse of our body. In everything we do, our back is there to lend balance from the pull of gravity, thus, it is very prone to injury and back problems. Most adults experience back problems, making it one of the most common reasons for medical visits and missed workdays.

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Most of the time, it is the lower back portion of the spine that is usually affected due to normal daily chores such as lifting heavy boxes, improper sitting position, slouching, a sudden awkward movement, or even sleeping on your stomach. Sports injuries from basketball and football, as well as stress on spinal bones and tissues can definitely cause back pain. Other more serious but rare cases of back pain involves spinal injuries such as cancer and infection of the spine. People with recurring back pains or multiple unsuccessful surgeries may develop chronic back pain.

Treatment and Medication
The good news is that back pain is easy to prevent and can be treated even at home. Simple body mechanics can help ease back pain problems within a few weeks. Treatment involves over-the-counter muscle relaxants and anti inflammatory drugs to reduce inflammation and relieve pain. Some tips like constant movement is ideal for healing and quick recovery. Extended bed rest is not advisable as this will aggravate back pain. Using support braces, corsets, back belts should be consulted with your doctors first. There are available braces in the market or your doctor may ask you to have one customized. However, some medical quarters are not in agreement with the idea of using braces. Some very few cases may need surgery and hospitalization unless there is severe pain and serious medical conditions.

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Pain relief drug ruled too costly for the NHS

August 2, 2007

Thousands of arthritis sufferers will be denied treatment with proven benefits by a decision not to pay for a new drug.

Guidance issued by the National Institute for Health and Clinical Excellence (NICE), the watchdog that controls access to drugs on the NHS, will recommend today that the drug does not represent value for money, although it has been shown to improve dramatically the severest symptoms of arthritis in almost half of patients.

The draft ruling comes on the day that Alan Johnson, the Health Secretary, will announce that he is tearing up a price-fixing agreement with pharmaceutical companies in an attempt to reduce unneccessary waste of drug funds.

The Times has learnt that the Health Secretary has decided to take on pharmaceutical giants as the NHS’s £8 billion annual drugs bill comes under pressure from expensive new medicines.
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Abatacept, which has the brand name Orencia, is the latest of a new generation of drugs to be blocked by NICE on the ground that it is not cost-effective.

About 400,000 people in the UK have rheumatoid arthritis, of whom a tenth (40,000) have a severe form. Many benefit from a class of drugs called anti-TNFs but about a third do not. This group, of around 12,000 patients, could potentially benefit from new drugs such as abatacept. Its manufacturer, Bristol Myers Squibb, estimated in its application to NICE that around 3,500 patients a year would benefit.

Published data shows that in trials abatacept produced a 50 per cent reduction in symptoms in about 40 per cent of the patients who used it in conjunction with an older drug, methotrexate.

The cost would be about £9,300 a year for an average patient, but all would be sufferers who had already been treated unsuccessfully with anti-TNF drugs, which are equally expensive. Those who gained no benefit would have been taken off the drug swiftly.

The NICE decision was described by patient groups as devastating. Ailsa Bosworth, chief executive of the National Rheumatoid Arthritis Society (NRAS), said: “This is extremely bad news for people living with severe rheumatoid arthritis.

“Denying patients the option of abatacept leaves some of them with the unacceptable choices of being put back on to treatments they have already failed on, palliative care or taking large doses of steroids, which have unacceptable side-effects over the long term.”

The NICE ruling will be open to consultation, and final guidance is not expected until the end of the year. A spokesman said: “Having examined cost-effectiveness analyses on the drug against a range of comparators, the committee concluded that abatacept could not be considered a costeffective use of NHS resources.”

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The problems of balancing drug costs against benefits have led a growing number of patients who are denied treatments to resort to legal action.

The Government hopes to free more money for treatments by renegotiating the five-year profit control agreement that it signed with drug companies just two years ago. The move comes after a report by the Office of Fair Trading recommended that the NHS move to a new system that matched the price it pays for drugs to how effective they are, after finding widespread evidence of overcharging.

Some of the most inflated prices are for treatments for blood pressure, cholesterol and stomach acid, which are prescribed to millions of patients a year. Although some cost ten times as much as alternatives they offer little or no extra benefit, the report found. It concluded: “We have identified hundreds of millions of pounds of expenditure per year that could be used more cost-effectively under value-based pricing, allowing patients greater access to drugs and other healthcare benefits they are currently being denied.”

Representatives of pharmaceutical firms were warned by Mr Johnson that he was intending to tear up the agreement. A statement from the Department of Health will seek to strike a conciliatory tone, emphasising the contribution made by drugs giants to the economy and in developing new medicines.

Nevertheless, the drugs industry is likely to fiercely resist attempts to renegotiate the price regulation scheme. In the wake of the competition watchdog’s report this year Richard Barker, the director-general of the Association of the British Pharmaceutical Industry, said: “The UK gets its life- improving and life-saving medicines at a fair and reasonable price.”

A Department of Health official told The Times that Mr Johnson could not ignore the findings of an independent watchdog after a thorough 18-month investigation that compared the prices paid in Britain with those paid abroad. He added that the Health Secretary had not yet decided whether to accept the recommendations in full.

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